HLA-G5 expression by trophoblast cells: the facts
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چکیده
منابع مشابه
HLA-G5 expression by trophoblast cells: the facts.
The non-classical HLA Class I molecule HLA-G was discovered at the fetal–maternal interface, but over the past few years, the tissue distribution of HLA-G in normal tissues has been found to be broader than originally reported: (i) HLA-G molecules have been detected from oocyte to blastocyst stage, then in invasive trophoblast, amniotic cells and fluid, endothelial cells from the chorionic vill...
متن کاملAllelic imbalance modulates surface expression of the tolerance-inducing HLA-G molecule on primary trophoblast cells.
The HLA-G molecule is expressed on trophoblast cells at the feto-maternal interface, where it interacts with local immune cells, and upholds tolerance against the semi-allogeneic fetus. Aberrant HLA-G expression in the placenta and reduced soluble HLA-G levels are observed in pregnancy complications, partly explained by HLA-G polymorphisms which are associated with differences in the alternativ...
متن کاملبررسی بیان آنتیژنهای HLA-G4 و HLA-G5 در خانمهای تهدید به سقط
Background and purpose: Major pathologic cause of abortions is unknown. HLA-G4 and HLA-G5 are two isoforms, membrane (G4) and soluble (G5) of nonclassical molecules of HLA-1b that can induce tolerance between mother and fetus. In this study, expression of two HLA-G isoforms and their effect were evaluated in threatened-abortion women in comparison with controls. Materials and methods: In a cas...
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Soluble human leukocyte antigen-G (HLA-G) is a non-classical class Ib HLA molecule that is secreted from blastocysts. Soluble HLA-G modulates the immune tolerance of the mother and can be used as a prognostic factor for the clinical pregnancy rate. However, the underlying mechanism of how soluble HLA-G5 affects pregnancy remains largely unknown. We hypothesized that soluble HLA-G5 promotes succ...
متن کاملHLA-G5 and G7 Isoforms in Pregnant Women.
Human leukocyte antigen-G which is an immune tolerance effecter molecule has an important role in the maintenance of fetus during pregnancy. Abortion is one of the complications of pregnancy period. In this research, we have studied levels of HLA-G 5, HLA-G7 isoforms in the abortion-threatened pregnant women in comparison with controls. In a case-control study, 101 abortion-threatened women an...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2005
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gah224